The Simpsons is basically a side-scrolling beat-em-up featuring the characters from The Simpsons TV show. The player can choose to play as each of the four Simpson characters. Homer, who punches and kicks; Marge, who swings her vacuum cleaner; Bart, who wields his skateboard; and Lisa, who uses a jump rope as a whip. Other weapons such as hammers and bowling balls are also available to use.

The game's levels are Downtown Springfield, Krustyland, Springfield Discount Cemetery, Moe's Tavern, Springfield Gorge, Dreamland, the Channel 6 studio, and the Power Plant. Each level ends with a boss whose speed and strength will increase after taking a certain amount of damage.

Between levels, the player can compete against the other characters in two mini-games to be first to complete a task (inflating a balloon and waking up their character).